Synthesis of a difluoromethyl xanthate compound has enabled a team of chemists to devise a convergent pathway to a new class of bioactive heterocyclic compounds. The difluorothiochromans, as they are called, could serve as building blocks to increase the diversity of heterocycle-based drugs. Pierre Salomon and of École Polytechnique, in France, originally prepared the xanthate as part of the Zard group’s metal-free strategy for generating fluorine-containing radical species for . . .
As part of the series Topics in Heterocyclic Chemistry,this volume titled Bio- tive Heterocycles II presents comprehensive and up-to-date reviews on selected topics regarding synthetic as well as naturally occurring bioactive heterocycles. The ?rst chapter, "High Pressure Synthesis of Heterocycles Related to Bio- tive Molecules" by Kiyoshi Matsumoto, presents a unique high-pressure s- thetic methodology in heterocyclic chemistry. Basic principles and fruitful examples for pericyclic reactions, such as Diels-Alder reactions, 1,3-dipolar reactions, and also for ionic reactions, such as S and addition reactions, are N discussed. The review will be of considerable interest to heterocyclic chemists and synthetic chemists. The second chapter, "Ring Transformation of Nitropyrimidinone Leading to Versatile Azaheterocyclic Compounds" by Nagatoshi Nishiwaki and Masahiro Ariga, presents a very critical review on novel ring transformations of di- tropyridones and nitropyrimidinones based on the work of his group. - dressed in this review is the synthesis of functionalized molecules, such as nitroanilines, nitropyridines, and nitrophenols, by the ring transformation of dinitropyridones as the nitromalonaldehyde equivalent. Ring transformations of nitropyrimidinones with dinucleophiles to 4-pyridones, pyrimidines and 4-aminopyridines, and to polyfunctinal pyridones with 1,3-dicarbonyl c- pounds, etc., are also discussed. This review may attract the interest of synthetic chemists as well as heterocyclic chemists in the life science ?elds. The third chapter, "Synthesis of Thalidomide" by Norio Shibata, Takeshi Yamamoto and Takeshi Toru, describes a modern synthetic aspect of thali- mide.
Dr. K. L. Ameta received his doctorate degree in Organic Chemistry from M. L. Sukhadia University, Udaipur, India in the year 2002. Presently, he is working as Assistant Professor of Chemistry, Faculty of Arts, Science and Commerce, Mody Institute of Technology and Science (Deemed University) Lakshmangarh, Rajasthan, India. He has vast experience of teaching both graduate and postgraduate level students. His research area involves synthesis, characterization and biological evaluation of different sized bioactive heterocyclic systems. In addition to this, he has keen interests in heterogeneous catalyzed organic synthesis and photocatalysis. He has published a number of research articles in various journals of national and international repute. Dr. (Mrs.) Anshu Dandia is working as Professor at Department of Chemistry, University of Rajasthan, Jaipur. Also, she is Coordinator, UGC-SAP Programme and Director, P. G. School of Physical Sciences and Affairs, Vigyan Bhawan, University of Rajasthan, Jaipur. Prof. Dandia has published over 160 research papers in the field of synthetic organic chemistry in the journals of international repute. Her fields of research interest are green and nanotechnology in organic synthesis, heterocyclic and medicinal chemistry and organo-fluorine chemistry. Moreover, she is honored as "Fellow of Royal Society of Chemistry (FRSC)", London in 2012; "Bronze medal" awarded by Chemical Research Society of India in 2012; "International Distinguished Women Scientist Award" in the international conference on "Chemistry for Mankind" organized by the joint venture of ACS, RSC and ISCB at Nagpur in 2011; "Top Researcher" award by the Vice Chancellor, University of Rajasthan based on highest H-index in the survey done by DST New Delhi in 2009. Apart from this, she is a dedicated teacher and strives to be abreast of new developments in teaching methodologies and she has received "Best Chemistry Teacher Award" in India by Tata Chemicals Ltd., Confederation of Indian Industries and the Association of Chemistry Teachers in Nov, 2012.